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KMID : 1033620120390030114
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Clinical and Experimental Reproductive Medicine
2012 Volume.39 No. 3 p.114 ~ p.117
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Blastocyst transfer in frozen-thawed cycles
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Han Ae-Ra
Park Chan-Woo
Lee Hyoung-Song
Yang Kwang-Moon
Song In-Ok
Koong Mi-Kyoung
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Abstract
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Objective: It is well known that fresh blastocyst transfer results in better pregnancy outcomes with a smaller number of transferred embryos compared with cleavage stage embryo transfer. However, in terms of frozen-thawed blastocyst transfer, only a few studies are available. We aimed to evaluate clinical outcomes of frozen-thawed embryo transfer (FET) with blastocysts.
Methods: Retrospective analysis of FET cycles with blastocysts (B-FET) between Jan 2007 and June 2009 was performed. Age-matched FET cycles with cleavage stage embryos (C-FET) during the same period were collected as controls. A total of 58 B-FET cycles were compared with 172 C-FET cycles and also compared with those of post-thaw extended culture blastocysts from frozen pronuclear stage embryos (22 cycles).
Results: There was no difference in the patient characteristics of each group. The embryos’ survival rates after thawing were comparable (>90%) and there was no difference in the implantation rate or clinical and ongoing pregnancy rate among the three groups.
Conclusion: In FET, blastocyst transfers may not present better pregnancy outcomes than cleavage stage embryo transfers. A further large-scale prospective study is needed.
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KEYWORD
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Frozen-thawed embryo transfer, Blastocyst, Pregnancy outcome
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